CAS Number: 9028-17-5
L-xylulose reductase
L-Xylulose reductase (XR) is an enzyme involved in the uronate cycle of glucose metabolism. It is part of the short-chain dehydrogenase/reductase (SDR) superfamily. Specifically, dicarbonyl/l-xylulose reductase (DCXR) is an enzyme with a critical role in carbohydrate metabolism and detoxification. Additionally, some experiments indicate that deficiency of the DCXR gene leads to a human clinical condition known as pentosuria.
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References
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The ‘true’ l-xylulose reductase of filamentous fungi identified in Aspergillus niger
The true L-xylulose reductase (LxrA) in the filamentous fungus Aspergillus niger was identified, resolving confusion from previous findings in Hypocrea jecorina. The gene lxrA (JGI177736) was found to be upregulated during growth on L-arabinose, and deletion of this gene resulted in a strain lacking NADPH-specific L-xylulose reductase activity with reduced growth on L-arabinose. The purified enzyme exhibited a Km of 25 mM for L-xylulose and a high specific activity (?max of 650 U/mg), confirming its role as the genuine L-xylulose reductase in the eukaryotic L-arabinose catabolic pathway.
DOI: 10.1016/j.febslet.2010.06.037