CAS Number: 1219-42-7
acetylpyridine benzoyl hydrazone
Acetylpyridine benzoyl hydrazone (APBH) is a hydrazone derivative of 2-acetylpyridine and benzoyl hydrazine. APBH forms a copper complex, denoted as [{(APBH)CuCl}2]·(EtOH), which has been structurally characterized as well. The copper complex is dimeric and exhibits a distorted octahedral geometry.
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References
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Structural chemistry and In vitro antitubercular activity of acetylpyridine benzoyl hydrazone and its copper complex against Mycobacterium smegmatis
The literature investigates acetylpyridine benzoyl hydrazone (APBH) and its copper complex, [{(APBH)CuCl}?]·(EtOH), through elemental analysis, magnetic measurements, spectroscopy, electrochemistry, and single-crystal X-ray diffraction. Structurally, APBH adopts a Z-isomeric form with a planar geometry, coordinating via the pyridyl nitrogen, azomethine nitrogen, and benzoyl carbonyl oxygen, while the copper complex forms a dimeric, distorted octahedral structure with two chloride bridges linking the copper atoms. In vitro antitubercular testing against Mycobacterium smegmatis reveals that complexation with copper significantly enhances the antimycobacterial activity compared to the free ligand.
DOI: 10.1016/S0960-894X(02)00855-7